Gene-silencing gene-silencing technique, Yukihide Maeda, a postdoctoral researcher resulted in Smith laboratory and lead author of the study, a mutated gene, the deafness caused in humans into the inner ear of mice. This gene acted through a dominant negative mechanism, and the mice had moderate hearing loss. Maeda introduced simultaneously developed the mutant gene and a short piece of interfering RNA specifically the gene the gene silenced. Standard hearing tests, of the mice. Used on newborn babies, confirmed that the treated mice were able to hear.
Richard Smith, Sterba Hearing Research Professor in Otolaryngology at the UI Roy J. And Lucille A. Carver College of Medicine, the as a proof – as a proof – of-principle experiments, but added that the success may point the way to new treatments for deafness in humans. We have a genetically deaf mouse interfering RNA that specifically prevents that a gene can be expressed, which were otherwise numbness By preventing its expression, we prevented the deafness, said Smith, was the senior author the study. Even though this is in the early stages, it’s really exciting, because there are other options for people who have hearing loss other than hearing aids or cochlear implants points. . Continue reading