Biodegradable microstructures can help repair tissue, prevent heart failure The delivery of tiny biodegradable microstructures to heart tissue damaged by coronary attack can help repair the tissue and stop upcoming heart failure. A group led by cardiovascular experts at the Medical University of Wisconsin bioengineered the microstructures to end up being the same size, stiffness and form as adult heart muscles cells, or cardiomyocytes, with the purpose of releasing biologically energetic peptides that become cardioprotective agents. The findings are released in Biomaterials. Paul Goldspink, Ph.D., associate professor of physiology at MCW, led the scholarly study.Nevertheless, the degree of the harm and whether it’s in part due to confounding environmental, genetic or physiological factors remains controversial. Using a specifically developed zebrafish, the researchers, Drs. Eva Shang and Irina Zhdanova, found that prenatal contact with cocaine, in concentrations comparable to those experienced by human embryos, modified the neuronal development in zebrafish and transformed embryonic expression of genes regulating development acutely, neurotransmission and circadian system. Moreover, we found that the consequences of the cocaine publicity were reliant on time of exposure, being more robust in the entire day, and had been blocked or attenuated by the main circadian hormone, melatonin, produced exclusively at night, said lead author Irina Zhdanova, MD, PhD, an associate professor in the section of neurobiology and anatomy at BUSM.